Effects of β-Carotene Supplementation on Molecular Markers of Lung Carcinogenesis in Male Smokers
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Authors' A Chicago, C Medical an Occupatio National In of Patholo 6Nutritional Genetics, Human Ser Correspon ology and G Room 3044 6829; E-ma
منابع مشابه
Effects of beta-carotene supplementation on molecular markers of lung carcinogenesis in male smokers.
Two primary prevention trials unexpectedly showed adverse effects of supplemental beta-carotene on lung cancer incidence in cigarette smokers. To elucidate the molecular mechanisms that might underlie these effects, we studied the immunohistochemical expression of cytochrome P450 1A1, 1A2, and 2E1, retinoic acid receptor beta, activated protein-1 elements, cyclin D1, and Ki67 in lung tumors and...
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Findings from several β-carotene supplementation trials were unexpected and conflicted with most observational studies. Carotenoids other than β-carotene are found in a variety of fruits and vegetables and may play a role in this important malignancy, but previous findings regarding the five major carotenoids are inconsistent. The authors analyzed the associations between dietary β-carotene, β-...
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In human clinical trials it was found that the putative chemopreventive agent -carotene not only failed to protect active smokers against the carcinogenic action of tobacco smoke, but actually increased their risk of developing lung cancer. In preclinical animal studies, -carotene had been effective against some chemically induced cancers, but not against tumors in the respiratory tract. We exp...
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Background: Vitamin E, β -carotene, and vitamin C are micronutrient antioxidants that protect cells from oxidative damage involved in prostate carcinogenesis. In separate trials, supplemental vitamin E was associated with a decreased risk of prostate cancer among smokers and supplemental β -carotene was associated with a decreased risk of prostate can cer among men with low baseline plasma β -c...
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Background Our recent findings have shown that the rat testis is subjected to significant oxidative stress during the early phase of diabetes induced by Streptozotocin (STZ). In the present study, we have investigated whether oral supplementation of β-carotene (BC) to pubertal rats would provide protection against diabetes associated oxidative stress in testis and liver. MaterialsAndMethods Mal...
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تاریخ انتشار 2010